Würzburg Childcare Study during the COVID-19 pandemic, part II (Wü-KiTa-CoV 2.0): Surveillance of SARS-CoV-2 infections in daycare centers (DCCs) via saliva sampling 2x/week for pooled PCR and/or antigen rapid tests performed at home (pilot project)

Würzburg Childcare Study during the COVID-19 pandemic, part II (Wü-KiTa-CoV 2.0): Surveillance of SARS-CoV-2 infections in daycare centers (DCCs) via saliva sampling 2x/week for pooled PCR and/or antigen rapid tests performed at home (pilot project) - Wü-KiTa-CoV 2.0

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00025546

Enrollment

591

Registered

2021-08-11

Start date

2021-04-16

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

SARS-CoV-2

Interventions

Group 1: Sampling of mouth-rinsing fluid of asymptomatic participants (daycare children and childcare workers) is done twice per week. Simultaneously, rapid antigen tests (as nasal swaps) are performe

Eligibility

Sex/Gender

All

Age

2 Years to 67 Years

Inclusion criteria

Inclusion criteria: Asymptomatic daycare children/childcare workers: Written consent for study participation from parents/guardians and childcare workers, respectively

Exclusion criteria

Exclusion criteria: After-school children, daycare staff without close contact to daycare children

Design outcomes

Primary

Measure	Time frame
Rate of initial acceptance of the three surveillance protocols (mouth-rinsing fluid + rapid antigen test, mouth-rising fluid only, rapid antigen test only; all twice per week) for the continuous screening for SARS-CoV-2 infections in daycare centers based on the initial consent by parents/guardians and childcare workers for respiratory sample collection.	—

Secondary

Measure	Time frame
Usability: Evaluation of the longer-term acceptance within the individual participating groups and for both methods of testing; Predictors for the acceptance; Evaluation of the psychosocial effects of the SARS-CoV-2 pandemic in association with the surveillance protocols; Satisfaction of the children; Effectivity: Evaluation of detection rates of SARS-CoV-2 infections in daycare centers, in total, within each participating group, and for each method of testing; Survey of basic data for SARS-CoV-2 antibodies (seroprevalence) in daycare children and childcare workers (point-of-care test via finger prick and ELISA from blood serum, respectively); Rate of false-positive and false-negative detections of SARS-CoV-2 via rapid antigen test for layman compared to simultaneous testing via PCR for asymptomatic participants; Duration between sampling and notification of a positive test result for PCR tests; Detection rates of SARS-CoV2 variants of concern (VOCs); Efficacy: Estimation of the costs for each surveillance protocol; Scalability: Evaluation of scalability and the suitability as strategy for a regional/supra-regional roll-out with regard to usability, effectiveness and efficiency; cost-benefits	—

Measure

Time frame

Usability: Evaluation of the longer-term acceptance within the individual participating groups and for both methods of testing; Predictors for the acceptance; Evaluation of the psychosocial effects of the SARS-CoV-2 pandemic in association with the surveillance protocols; Satisfaction of the children; Effectivity: Evaluation of detection rates of SARS-CoV-2 infections in daycare centers, in total, within each participating group, and for each method of testing; Survey of basic data for SARS-CoV-2 antibodies (seroprevalence) in daycare children and childcare workers (point-of-care test via finger prick and ELISA from blood serum, respectively); Rate of false-positive and false-negative detections of SARS-CoV-2 via rapid antigen test for layman compared to simultaneous testing via PCR for asymptomatic participants; Duration between sampling and notification of a positive test result for PCR tests; Detection rates of SARS-CoV2 variants of concern (VOCs); Efficacy: Estimation of the costs for each surveillance protocol; Scalability: Evaluation of scalability and the suitability as strategy for a regional/supra-regional roll-out with regard to usability, effectiveness and efficiency; cost-benefits

—

Countries

Germany

Contacts

Public ContactStudiensekretariat Wü-KiTa-CoV

Institut für Hygiene und Mikrobiologie, Universität Würzburg

wuekitacov@uni-wuerzburg.de0931/3187592

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 11, 2026