I65.2 I10-I15
Conditions
Interventions
Group 1: Prospective investigation of the progression of carotid aretry atherosclerosis and analysis of the occurrence of cerebral or retinal ischemia during the 2-years follow-up period
Sponsors
Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
No minimum to 90 Years
Inclusion criteria
Inclusion criteria: - >/= 90 years of age - asymptomatic 20-80% ICA stenosis (NASCET criteria) - one additional cardiovascular risk factor (hypertension, smoking habit, diabetes mellitus, hyperlipidemia, peripheral artery disease, coronary heart disease, familial predisposition)
Exclusion criteria
Exclusion criteria: - lack of ability to consent - refusal of study participation - contraindications against 3 Tesla MRI (such as ferromagnetic implants, claustrophobia) - bad clinical condition (modified ranking scale >3) - atrial fibrillation or other relevant cardiac arrhythmias due to the interference with the ECG-trigger during 4D flow MRI - expectation of life 100 kilometers - scheduled carotid artery endarterectomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of independent predictors of of a) progression of carotid artery atherosclerosis and b) cerebrovascular events (cerebral or retinal ischemia) using 4D flow MRI and 4D flow MRI in conjunction with computer-augmentation (wall shear stress, plaque surface pressure, oscillatory shear index) | — |
Countries
Germany
Contacts
Public ContactJonathan Andrae
Neurologische Uniklinik
Outcome results
None listed