Prospective controlled long-term study to investigate cognitive impairment in patients with previous treatment to intensive care units (ICU), with and without SARS-CoV-2-infection and in mild COVID-19 patients without previous ICU treatment

Prospective controlled long-term study to investigate cognitive impairment in patients with previous treatment to intensive care units (ICU), with and without SARS-CoV-2-infection and in mild COVID-19 patients without previous ICU treatment - postCoV-Cog

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00025523

Enrollment

Registered

2021-06-21

Start date

2021-06-04

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 G62 G72 U07.1

Interventions

Group 1: patients with COVID-19 infection and previous treatment at ICU Group 2: patients (CIP/CIM) without COVID-19 infection and previous treatment at ICU Group 3: Non-hospitalized patients after mi

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: - Age: 18-90 - Written informed consent COVID-19 groups: -COVID-19 infection confirmed by PCR test -COVID-ITS group: COVID-19 associated rehabilitation diagnosis (CIP/CIM) and ITS duration >= 1 week -mild infection: no treatment in hospital; quarantine at home; acute infection >= 12 weeks Non-COVID-19 group CIP/CIM rehabilitation diagnosis and ITS duration >= 1 week (primary pulmonar disease or other non cerebral cause)

Exclusion criteria

Exclusion criteria: Patients with -Condition after cardiopulmonary resuscitation (COR) -acute as well as pre-existing structural brain damage -pre-existing dementia or other neurodegenerative disease -severe hepatic insufficiency (hepatic encephalopathy) -CIP/CIM control patients: proven COVID-19 infection

Design outcomes

Primary

Measure	Time frame
Cognitive performance in relevant domains: - Attention (TAP) - Executive function (TAP, word fluency) - Working memory (repeating numbers) - verbal memory (VLMT) will be assessed several times during hospital (rehabilitation clinic) stay (ITS patients) at least 12 weeks after acute infection (ITS patients, patients after mild course) a follow-up measurement will be performed	—

Secondary

Measure	Time frame
a) global cognition (MoCA) b) Patient reported outcome measures (quality of life, sleep qualilty, anxiety depression, fatigue) c) further cognitive tests d) optional: cMRT anatomical and functional sequences, DTI (collaboration with the Prof. Finke and BCAN, Charité Berlin) e) Lumbar puncture if clinially indicated (e.g. encephalopathic syndrom, Delir, unclear persistent (subjective) cognitive deficits); analysis of specific antibodies (collaboration with Prof. Prüß, Charité Berlin) f) medical data like length of stay in hospital, duration of ventialtion, complication during inpatient stay, medication, therapies, labor parameters, neurological scores, care level) g) optional: resting state EEG during the long-term follow-up visit to measure neuronal EEG correlates (frequency and coherence parameters)	—

Measure

Time frame

a) global cognition (MoCA) b) Patient reported outcome measures (quality of life, sleep qualilty, anxiety depression, fatigue) c) further cognitive tests d) optional: cMRT anatomical and functional sequences, DTI (collaboration with the Prof. Finke and BCAN, Charité Berlin) e) Lumbar puncture if clinially indicated (e.g. encephalopathic syndrom, Delir, unclear persistent (subjective) cognitive deficits); analysis of specific antibodies (collaboration with Prof. Prüß, Charité Berlin) f) medical data like length of stay in hospital, duration of ventialtion, complication during inpatient stay, medication, therapies, labor parameters, neurological scores, care level) g) optional: resting state EEG during the long-term follow-up visit to measure neuronal EEG correlates (frequency and coherence parameters)

—

Countries

Germany

Contacts

Public ContactChristiana Franke

Charité - Universitätsmedizin Berlin Klinik für Neurologie mit Experimenteller Neurologie

christiana.franke@charite.de030450560769

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 29, 2026