G47.31
Conditions
Interventions
Group 1: It is an exploratory study.
Specific immune cell populations (T-cells (regulatory T-cells, CD4 + / CD8 +, naive / memory T-cells, ?d T-cells), dendritic cells (cDC1, cDC2, pDC), natural kille
Sponsors
Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Hals-, Nasen-, Ohrenklinik und Poliklinik
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patient in the Sleep Medicine Centre & Sleep Research Lab, Dept. of Otorhinolaryngology Head & Neck Surgery, University Medical Center Mainz; Willingness to participate in the study; Suspicion of Obstructive Sleep Apnea; Snoring or daytime sleepiness or observed breathing interruptions during sleep or an AHI = 5 / h screened by an outpatient cardiorespiratory polygraph; Currently no therapy for breathing-related sleep disorders (e.g. continuous positive airway pressure: CPAP); No prior surgical procedure for OSA; Age of the participant: > 18 years; German and / or English language skills
Exclusion criteria
Exclusion criteria: Age of the participant: 35 kg / m²); COPD (chronic obstructive pulmonary disease); Heart failure; Active malignant disease (5 years after finishing the corresponding therapy); Hematological diseases (e.g. myelodysplastic syndrome); diagnosed immune deficiency (e.g. AIDS); Clinically relevant atherosclerosis (status post myocardial infarction, unstable angina pectoris, status post stroke, status post stenting of the coronary or peripheral arteries, status post surgery for peripheral arterial occlusive disease); Chronic active inflammatory diseases (psoriasis, rheumatoid arthritis, Wegener's disease, sarcoidosis, syst. Lupus erythemadotes, other autoimmune diseases); Active specific infections (e.g. tuberculosis); Chronic therapy with oral steroids, immunosuppressants (e.g. cyclophosphamide, azathioprine or antibodies (immunotherapy); Recently (within the last 4 weeks) history of vaccinations (e.g. against Covid-19)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration / activity of blood CD4 + / CD8 + T cells | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentration / activity of blood dendritic cells (cDC1, cDC2, pDC) | — |
Countries
Germany
Contacts
Public ContactHaralampos Gouveris
Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Hals-, Nasen-, Ohrenklinik und Poliklinik
Outcome results
None listed