Ischemia-reperfusion injury
Conditions
Interventions
Group 1: Intervention group: RIC is performed by repetitively inflating and deflating a standard blood pressure cuff placed on the upper arm (three 10 min cuff inflations and deflations) one day preop
Sponsors
Universitätsklinikum Regensburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Free flap surgery
Exclusion criteria
Exclusion criteria: Children, patients with a health care proxy, contraindications for blood pressure cuff inflation (e.g. post-traumatic, vascular disease) or indocyanine-green fluorescence angiography (e.g. manifest hyperthyroidism, iodine allergy)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome measure: The fractional weight of insufficiently perfused and resected flap tissue related to total flap weight is measured based on clinical examination and Indocyanine green fluorescence angiography according to the study center's clinical routine. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures: occurrence / severity of wound healing disturbances, revision surgery, other postoperative complications (e.g. fat necrosis, oil cysts). These parameters are assessed over a six week postoperative period via clinical examination, further non-invasive diagnostic measures (e.g. ultrasound) and photo documentation. | — |
Countries
Germany
Contacts
Public ContactAlexandra Anker
Universitätsklinikum Regensburg
Outcome results
None listed