G24.3
Conditions
Interventions
Group 1: Patients with cervical dystonia (with and without tremor): Standard therapy with Pridinol toxin and collection of additional scales and questionnaires.
Sponsors
Universitätsklinikum Schleswig-Holstein (UKSH)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with cervical dystonia and a diagnosis> than 2 years of age - Torticollis must be part of cervical dystonia - Moderate to severe dystonia with> 15 points on the motor part of the TWSTR scale - Last BoNT injection prior to inclusion in the study at least 12 weeks ago - Medical Indication for the use of Pridinol and no contraindications - the patient must be able to give consent
Exclusion criteria
Exclusion criteria: - Cervical dystonia without torticollis - Generalized dystonia - Severe depression or suicidality - Psychoses - Dementia - Pregnancy - Glaucoma, prostate hypertrophy, urinary retention, gastrointestinal obstruction, cardiac arrhythmias - Drug or alcohol addiction - Participation in another dystonia study during the benzodiazepine or anticholinergic drugs last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome parameter will be the correlation between the TETRAS / TWSTR and the DNMSQuest. We expect an association between a reduction in the motor scales and the DNMSQuest. | — |
Secondary
| Measure | Time frame |
|---|---|
| Association of the motor scales with Beck's Depression Inventory (BDI), Columbia assessment scale for suicidality (C-SSRS), quality of life scale (EQ-5D) and cognition, the Schmahmann scale | — |
Countries
Germany
Contacts
Public ContactJos Becktepe
Klinik für Neurologie, UKSH, Campus Kiel
Outcome results
None listed