C18 C19 C20
Conditions
Interventions
Group 1: Arm 1 - colon cancer
-> 16sRNA microbiome analysis (stool at time of initial diagnosis/ stool post operative/ stool during follow up
healthy normal tissue of the proximal and distal resection margin
tumor tissue)
Group 2: Arm 2 - rectal cancer
-> 16sRNA microbiome analysis (stool examination at time of initial diagnosis/ if neoad. therapy than stool examination after completion of neoadj. therapy
tumor tissue)
Sponsors
Universitätsklinikum Greifswald
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - histologically confirmed CRC, or suspicion of CRC - Age greater than or equal to 18 years
Exclusion criteria
Exclusion criteria: - Pregnancy/ nursing women - Patients unable to give consent - Secondary neoplasia < 5 years prior to study inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 16sRNA analysis of the microbiome (stool at initial diagnosis and postoperatively at primary surgery, or before neoadj. therapy and after completion, tumor tissue intraoperatively) in patients with CRC. | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival Tumor-free survival Changes of the microbiome under therapy by 16sRNA analysis | — |
Countries
Germany
Contacts
Public ContactMelanie Langheinrich
Klinik und Poliklinik für Allgemeine Chirurgie, Viszeral,- Thorax- und Gefäßchirurgie
Outcome results
None listed