Healthy volunteers N18
Conditions
Interventions
Group 1: Uptake of different vitamin K forms after a single oral administration of vitamin K1 and menaquinones-4 and -7
Sponsors
Universitätsklinikum der RWTH Aachen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: stable, chronic hemodialysis patients •Age of = 18 years •Written informed consent prior to study participation •The subject is willing and able to follow the procedures outlined in the protocol Control group: •Normal renal function •Age- and sex-matched written informed consent prior to study participation •The subject is willing and able to follow the procedures outlined in the protocol
Exclusion criteria
Exclusion criteria: •Age less than 18 years •Severe medical events within the last three months •Planned surgery for the duration of the sampling •Acute/chronic gastrointestinal infections •Recent or ongoing antibiotic therapy •Conditions that impair vitamin K uptake or metabolism (chronic inflammatory bowel disease, intake of vitamin K antagonists) •Smokers •Severe dyslipidemia •Severe anemia, defined as hemoglobin level less than 9.0 g/dl
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of vitamin K content in liporoteins until 6 hrs after ingestion | — |
Countries
Germany
Contacts
Public ContactJürgen Floege
Universitätsklinik der RWTH AachenMedizinische Klinik II
Outcome results
None listed