G93.2 I67.6 G97.1 G44.8
Conditions
Interventions
Group 1: Patients with idiopathic intracranial hypertension:
Subproject 1 comprises the examination of patients with headache under IIH before and after lumbar CSF opening pressure measurement and, i
Sponsors
Neurologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion Criteria for verum group age over 18 german mother tongue Headache associated with IIH or SIH or SVT signed informed consent Inclusion Criteria for controll group age over 18 german mother tongue max. of 2 days of not severe headache per month no primary headache disorder (exception: episodic tension type headache) signed informed consent
Exclusion criteria
Exclusion criteria: Exclusion Criteria for verum group age 30 kg/m2 other headache disorders (not episodic migraine or episodic tension type headache) hypertension CGRP (Receptor) antibodies in the last 3 months severe internal, neurological, psychiatric disorders, actual intake of triptans or other pain-medication in the last 48 hours before the visit, Headache on the day of the examination
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantify trigeminal CGRP release in patients with headache under IIH, SVT, and SIH by measuring CGRP levels in tear fluid and plasma (and cerebrospinal fluid in IIH) compared with controll group. | — |
Secondary
| Measure | Time frame |
|---|---|
| -correlation of CGRP level with CSF opening pressure in patients IIH and correlation of CGRP level in CSF with CGRP level in tear fluid and serum in patients. Level in tear fluid and serum in patients. - Correlation of CGRP level (plasma, CSF, tear fluid) before and after puncture in IIH patients - Analysis of localization and extent of SVT compared to CGRP- levels in tear fluid and serum. | — |
Countries
Germany
Contacts
Public ContactCem Thunstedt
Neurologie
Outcome results
None listed