Pain and itch
Conditions
Interventions
Group 1: This is not an AMG or MPG study. Only healthy volunteers are taking part.
We investigate signalling pathways of itching in healthy volunteers in contrast to signalling pathways of pain. For
Sponsors
Forschergruppe Neurowissenschaften IZKF Uniklinik Aachen der RWTH Aachen
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. healthy subjects without regular medicaiton except oral contraceptives or low dose thyroid hormones. 2. Between 18 and 80 years old. 3. ability to give consent 4. Ability to sit up to 7 hours without using the toilette.
Exclusion criteria
Exclusion criteria: 5. Serious illness or serious traumata at legs or feet in the past. 6. Increased risk of thrombosis or blood clotting. 7. preagnancy or breast feeding. 8. Chronic disease or health condition, which alteres nerve function, skin or immune system. 9. allergies which require constand medicaiton. 10. Internal defibrillator or heart pacemaker.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The activity of peripheral unmylinised nerve fibres is measured via microneurography in response to various itchy mediators applied to the skin. The aim is to find out which nerve fibres cause the sensation of ‘itching’ as opposed to the sensation of ‘pain’ and by what type of activity. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary aim is to describe different signalling patterns that encode heat pain versus chemically induced itching. | — |
Countries
Germany
Contacts
Public ContactBarbara Namer
Forschergruppe Neurowissenschaften IZKF Uniklinik Aachen der RWTH Aachen
Outcome results
None listed