F95.2
Conditions
Interventions
Group 1: Patients with Tourette's syndrome will be interviewed once and asked to perform computerized tasks.
During the course of the study, the following assessments will be administered:
1) various
Sponsors
Klinik für Stereotaxie und funktionelle Neurochirurgie, Klinikum der Universität zu Köln
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Fluent in the German language. ICD 10 Diagnosis of severe TD by expert clinician. Chronic thalamic DBS for at least 12 weeks.
Exclusion criteria
Exclusion criteria: Active suicidal or homicidal ideation within last 6 months Current psychotic symptomatology Active or recent substance abuse (except intake of cannabis-based substances, if consumed for treatment of tics and if they are paused 72 hours before the experiment) Serious systemic medical disease that requires treatment Clinically relevant neurological disorder of the central nervous system such as stroke, epilepsy, neoplasia Mental retardation or other unstable psychiatric disorder that requires treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Pre-Pulse Inhibition measured as difference in amplitudes in the electromyogram (EMG) between trials with and without Pre-Pulse | — |
Secondary
| Measure | Time frame |
|---|---|
| 2) Reaction times dependent on the validity of a stimulus 3) Reaction times in self-initiated and visually cued reactions as well as the ratio of self-initiated vs. visually cued reactions | — |
Countries
Germany
Contacts
Public ContactThomas Schüller
Klinik für Psychiatrie und Psychotherapie, Klinikum der Universität zu Köln
Outcome results
None listed