Reduction of stress-induced modulation of memory reactivation through transcranial magnetic stimulation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00025204

Enrollment

Registered

2021-05-06

Start date

2021-05-21

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Basic science study investigating stress effects on behavioral and neural correlates of memory processes with potential implications for stress-associated disorders such as PTSD and depression.

Interventions

Group 1: 1st experimental group: stress + brain stimulation (TMS

iTBS, 3min). Group 2: 2nd experimental group: stress + sham brain stimulation (Sham-TMS

iTBS, 3min). Group 3: 3rd experimental group: control procedure + brain stimulation (TMS

iTBS, 3min). Group 4: Control group: control procedure + sham brain stimulation (Sham-TMS

iTBS, 3min).

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: - very good knowledge of German -Right-handed

Exclusion criteria

Exclusion criteria: -study psychology, -smoking, -pregnancy -using hormonal contraceptives (e.g. -pill, ring, patch, etc.), -wearing metal on/in the body (e.g. stents, -copper coil, piercings that cannot be removed). -acute diseases -taking medications, -have history of neurological or mental disorders. - grid or baldness (EEG not possible)

Design outcomes

Primary

Measure	Time frame
Investigation of the influence of a psychosocial stressor and the application of a unit of transcranial magnetic stimulation or sham stimulation before memory reactivation on memory performance and the brain processes involved. Memory performance is assessed on the second day of the examination, after the application of TMS and the stressor, by means of a computer-based test. In this test, old words (learned on day 1) and new words are presented. The subjects must first indicate whether the word shown is old or new, and then indicate which picture belonged to this word.	—

Measure

Time frame

Investigation of the influence of a psychosocial stressor and the application of a unit of transcranial magnetic stimulation or sham stimulation before memory reactivation on memory performance and the brain processes involved. Memory performance is assessed on the second day of the examination, after the application of TMS and the stressor, by means of a computer-based test. In this test, old words (learned on day 1) and new words are presented. The subjects must first indicate whether the word shown is old or new, and then indicate which picture belonged to this word.

—

Secondary

Measure	Time frame
Knowledge of the influence of stress, brain stimulation, and their combination on memory reactivation and related changes in neural correlates.	—

Countries

Germany

Contacts

Public ContactHendrik Heinbockel

Universität Hamburg

hendrik.heinbockel@uni-hamburg.de040 42838-9848

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026