Investigation of nociceptors in bortezomib-induced peripheral neuropathy

Investigation of nociceptors in bortezomib-induced peripheral neuropathy - Resolve Pain IN-BIPN

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00025196

Enrollment

120

Registered

2021-05-03

Start date

2020-08-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C90.0 G62.0

Interventions

Group 1: Newly diagnosed patients which just begun the treatment with bortezomib : investigation of nociceptors by QST, C-fiber test and skin biopsies Group 2: Patients in actual treatment with borte

with and without existing peripheral neuropathy: investigation of nociceptors by QST, C-fiber test, and skin biopsies. Group 3: Patients with completed treatment with bortezomib

with and without existing peripheral neuropathy: investigation of nociceptors by QST, C-fiber test, and skin biopsies.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Multiple Myeloma diagnosed according to current IMWG criteria.

Exclusion criteria

Exclusion criteria: Serious other medical condition that would prevent subject from study participation

Design outcomes

Primary

Measure	Time frame
intraepidermal nerve fiber density (IENFD): density of intraepidermal nerve fibers	—

Secondary

Measure	Time frame
Quantitative sensory testing (QST) : temperature sensitivity threshold	—

Countries

Germany

Contacts

Public ContactClaudia Sommer

Universitätsklinikum Würzburg Neurologische Klinik

claudia.sommer@uni-wuerzburg.de0931/2010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026