Novel Identified complement regulatory functions of physiological proteins: Mechanisms, physiological relevance and potential for therapeutic applications

Novel Identified complement regulatory functions of physiological proteins: Mechanisms, physiological relevance and potential for therapeutic applications - TSP-Comp

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00025182

Enrollment

Registered

2021-06-29

Start date

2021-08-09

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C3 glomerulonephritis N05

Interventions

Group 1: By adding the protein of interest to serum from patients, it will be shown that the overactivated complement system can be regulated.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with the following diagnoses: typical, atypical hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, C3 gloerulopathy, IgA nephritis, Schoenlein-Hennoch purpura nephritis or ANCA vasculitis and healthy controls.

Exclusion criteria

Exclusion criteria: missing consent to biomaterial database

Design outcomes

Primary

Measure	Time frame
The protein studied shows measurable complement regulation or complement activation on patient samples.	—

Secondary

Measure	Time frame
Influence of the investigated protein on the pathomechanism	—

Countries

Germany

Contacts

Public ContactKarsten Häffner

Medical Center - University of Freiburg, Renal Division, Department of Medicine

karsten.haeffner@klinikum.uni-freiburg.de+49 761 270-43000

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026