C71.9 C79.3
Conditions
Interventions
Group 1: Patients with brain tumors close to motoric eloquent areas receive a navigated transcranial megnetic stimulation (nTMS) examination prior to brain tumor surgery.
After the nTMS-examination a
Sponsors
Klinik für Neurochirurgie Klinikum Nürnberg Paracelsus Medizinische Privatuniversität
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patient with brain tumors Gross total resection or subtotal resection is to achieve supratentorial tumor localisation tumor localisation close to functional motor area or patients symptomatic with motor deficits suspected tumor entity: primary or secondary brain tumor surgical treatment of every of the patient's tumorous lesions
Exclusion criteria
Exclusion criteria: no MRI possible (cochlea implant, cardiac pacemaker, other implants that do not allow MRI) CSF fluid diversion patients with deep brain stimulation devices, spinal cord stimulator or medication pumps patient refuses participation patient cannot consent patients who receive additional nrTMS language mapping pregnant or breastfeeding female patients patients with exclusively infratentorial lesions patients with suspected meningiomas as lesions that should be treated patients under dialysis patients with coronary heart disease (myocardial infarction or cardiac stents) patients with cardiac arrhythmia (first degree AV-block excluded) cardiac failure NYHA III and NYHA IV
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in tumor diameter (mm) preoperatively and postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference of tumor volume (cm³) preoperatively and postoperatively Postoperative neurological status (motor function MRC grade) Postoperative neurological status (NIHSS) prognostic value of nTMS for postoperative motor function prognostic value of nTMS-DTI fibertracking for postoperative motor function prognostic value of the distance to fiber tracts regarding residual tumor size improvement in nTMS-examination setting according to the answers of the patient questionnaire association between postoperative DTI-fibertracking and neurologic outcome | — |
Countries
Germany
Contacts
Public ContactThomas Eibl
Klinik für Neurochirurgie Klinikum Nürnberg Paracelsus Medizinische Privatuniversität
Outcome results
None listed