F00 F01 F02 F03
Conditions
Interventions
Group 1: Intervention Group: 30 min. IHHT + 20 min. aerobic training on a recumbent cycling ergometer (6 weeks, 3 sessions per week)
Group 2: ControlGroup: 30 min. sham-IHHT (breathing normoixc air) +
Sponsors
Otto-von-Guericke-Universität Magdeburg Fakultät für Humanwissenschaften Institut III: Sportwissenschaft Lehrstuhl Gesundheit und körperliche Aktivität
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: - Residents of a geriatric facility - Acceptance of the procedure (mask breathing). - Voluntary participation and signing of the informed consent
Exclusion criteria
Exclusion criteria: - Smoker - Obisity - Symptoms of severe dementia that limit participation in the study (low compliance of participants) - Cardiovascular disease such as untreated hypertension, coronary artery disease with unstable angina pectoris (CCS 3-4), severe heart failure (NYHA III-IV), and arrhythmias - Untreated or uncontrolled diabetes mellitus - Pulmonary fibrosis - Cancer - Acute inflammatory diseases - Need for continuous or intermittent ventilation and/or oxygenation - Arterial oxygen saturation at rest of less than 93%. - simultaneously participation in other interventions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in global cognitive function via Dementia-Detection-Test (Pre-Test: within one week before Intervention, Post-Test: within one week after Intervention) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Changes in cognitive functions using clock-drawing test (pre-test: within one week before intervention start, post-test: within one week after intervention end). - Changes in physical performance using i) timed-up and go test, ii) short physical performance battery test, iii) 6-minute walk test, and iv) grip strength (pre-test: within one week before start of intervention, post-test: within one week after end of intervention) - Changes in hemodynamic status using i) resting systolic and diastolic blood pressure (within one week before intervention, after 6 and 12 training sessions, and within one week after intervention) and ii) electrocardiogram (pre-test: within one week before start of intervention, post-test: within one week after end of intervention) - Acute and chronic changes in blood biomarkers: i) serum and ii) plasma brain-derived neurotrophic factor, iii) serum C-reactive protein, iv) serum interleukin 6, v) total cholesterol, vi) high and vii) low density lipoprotein, and viii) triglycerides (immediately before and after the first training session and immediately before and after the last training session) - Changes in subjective feelings using i) Geriatric Depression Scale, ii) EQ-5D-5L, and iii) Quality of Life in Alzheimer's Disease Questionaire (pre-test: within one week before the start of the intervention, post-test: within one week after the end of the intervention) - Changes in dopaminergic activity using Eye Blinking Rate (pre-test: within one week before intervention start, post-test: within one week after intervention end). - Hypoxia tolerance by hypoxia test (within one week before intervention, after 9 training sessions and within one week after intervention). | — |
Countries
Germany
Contacts
Public ContactTom Behrendt
Otto-von-Guericke-Universität Magdeburg Fakultät für Humanwissenschaften Institut III: Sportwissenschaft Lehrstuhl Gesundheit und körperliche Aktivität
Outcome results
None listed