I60 I63
Conditions
Interventions
Group 1: Subjects in the neurointensive care unit or the neurological/neurosurgical/medical wards will be identified by a study investigator. Patients will be screened and enrolled consecutively.
1.
if no consent of patient or a legal representative is available during hospital stay, the bioprobes will be destroyed
if consent is available during hospital stay, patients will be included at this timepoint.
2. Demographic, clinical, and imaging information will be documented by a study investigator in a standardize
Sponsors
Universitätsklinikum Augsburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Age =18 years - Spontaneous non-traumatic subarachnoid hemorrhage (aneurysmal or non-aneurysmal) - Patient or patient representative giving informed consent - Study enrollment within 48 hours from symptom onset
Exclusion criteria
Exclusion criteria: - Recent (within the past 3 months) history of: ischemic stroke, hemorrhagic stroke, myocardial infarction, venous thromboembolism. - Any past medical history of: rheumatoid arthritis, systemic lupus erythematosus, cancer, hereditary coagulopathy, subarachnoid hemorrhage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The plasma concentration of the following biomarkers on post subarachnoid hemorrhage day 2, day 7, and day 10 (the day of the ictus is counted as day 0). Each blood collection can be performed , +-1 day. Analyzed biomarkers: - Cell-free DNA - Nucleosomes / histones - DNA-myeloperoxidase (MPO) complexes or DNA-neutrophil elastase (NE) complexes - Citrullinated histones - Peptidylarginine deaminase 4 (PAD4) | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment for delayed cerebral ischemia on routinely obtained imaging (computed tomography or magnetic resonance imaging of the brain) at any point in time between 48 hours after aneurysm occlusion and 6 weeks after the index bleed, whenever deemed clinically appropriate. The radiological assessment of delayed cerebral ischemia follows the published consensus definition of the Neurocritical Care Society multidisciplinary research group. | — |
Countries
Germany
Contacts
Public ContactHauke Schneider
Universitätsklinikum Augsburg
Outcome results
None listed