Calcium-sensitizing and calcium-desensitizing mechanisms of vascular smooth muscle: Heterogineity of vascular beds and age-related differences

Calcium-sensitizing and calcium-desensitizing mechanisms of vascular smooth muscle: Heterogineity of vascular beds and age-related differences - PK-Vessel

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00025021

Enrollment

Registered

2021-05-10

Start date

2021-04-21

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vascular aging

Interventions

Group 1: Patients from whom a kidney sample was obtained Group 2: Patients from whom a mesenteric sample was obtained

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Patients who undergo elective surgery and who gave consent that a tissue sample from resected material may be used for Research purposes

Exclusion criteria

Exclusion criteria: overt coronary artery disease, peripheral artery disease, advanced renal failure (stage 3, GFR 30-59 ml/min/1,73m2), chronic inflammatory disease

Design outcomes

Primary

Measure	Time frame
The aim of the study is to identify differential contributions of signaling mechanisms to vasoconstriction and vasodilation in human resistance arteries. Another aim is to identify age-dependent alterations in vascular tone regulation.	—

Countries

Germany

Contacts

Public ContactOlaf Grisk

Medizinische Hochschule Brandenburg

olaf.grisk@mhb-fontane.de03391 3914713

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026