Endoscopic mucosal resection (EMR) versus endoscopic submucosal dissection (ESD) for early Barrett´s neoplasia: a retrospective single center analysis of efficacy, complication and recurrence rates

Endoscopic mucosal resection (EMR) versus endoscopic submucosal dissection (ESD) for early Barrett´s neoplasia: a retrospective single center analysis of efficacy, complication and recurrence rates - /

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00025016

Enrollment

150

Registered

2021-04-20

Start date

2023-06-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K22.7 C15.5

Interventions

Group 1: EMR of early Barrett´s neoplasia Group 2: ESD of early Barrett´s neoplasia

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: EMR or ESD in the period from 01/01/2003 to 12/31/2020 with endoscopic visible suspicious Barrett´s lesion or a histologically confirmed Barrett´s associated HGIEN or an early Barrett's carcinoma

Exclusion criteria

Exclusion criteria: - age <18 years - squamous cell neoplasia - signs for tumor infiltration of the tunica muscularis in endoscopic ultrasound - Metastasis at the time of index intervention

Design outcomes

Primary

Measure	Time frame
combined primary endpoint of 1. endoscopically complete resection of Barrett's neoplasia (carcinoma or HGIEN) with neoplasia-free resection margin vertical - R0, L0, V0 - and - 2. Neoplasia-free survival in the follow-up of 12 months, defined by excluding Barrett's carcinoma or HGIEN in endoscopic follow-up	—

Secondary

Measure	Time frame
- complication rate, defined as perforation requiring intervention (haemoclip, stent, surgery) or major bleeding (endoscopic intervention, blood transfusion) periinterventionally and within 30 days - Peri- or post-interventional minor bleeding within 30 days - Percentage of post-interventional strictures requiring further therapeutic interventions - Mortality within 30 days and 3 months - Recurrence-free survival in follow-up of at least 6, 12, 24, 36, 48 and 60 months - en bloc resection of Barrett's neoplasia - Percentage of required re-resection if the R0 resection is primarily absent - duration of the procedure	—

Measure

Time frame

- complication rate, defined as perforation requiring intervention (haemoclip, stent, surgery) or major bleeding (endoscopic intervention, blood transfusion) periinterventionally and within 30 days - Peri- or post-interventional minor bleeding within 30 days - Percentage of post-interventional strictures requiring further therapeutic interventions - Mortality within 30 days and 3 months - Recurrence-free survival in follow-up of at least 6, 12, 24, 36, 48 and 60 months - en bloc resection of Barrett's neoplasia - Percentage of required re-resection if the R0 resection is primarily absent - duration of the procedure

—

Countries

Germany

Contacts

Public ContactChristian Meinhardt

Klinikum Oldenburg AöR, Universitätsklinik für Innere Medizin - Gastroenterologie, Hepatologie, Stoffwechselmedizin, Nieren- und Hochdruckerkrankungen

meinhardt.christian@klinikum-oldenburg.de0441-403-0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026