O14 O36.5
Conditions
Interventions
Group 1: Pregnant women at risk for development of pre-eclampsia get repeated analyses of the peripheral and retinal arterial vessels by peripheral arterial tonometry (EndoPAT) and Dynamic Vessel Anal
Sponsors
Universitätsfrauenklinik und Poliklinik am Klinikum Südstadt Rostock
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: pregravid obesity (body mass index equal or greater 30 kg/squaremeters befor pregnancy) and/or mean pulsatility index (PI) of the uterine arteries greater than 95. centile
Exclusion criteria
Exclusion criteria: person not capable of giving consent, no informed consent, intrauterine fetal death, chromosomal aberrations, severe fetal malformations, premature preterm rupture of membranes, known anti-phospholipid syndrome, history of pre-eclampsia or pregnancy induced hypertension in a previous pregnancy, multiple gestation, chronic kidney disease, diabetes mellitus type 1, eye diseased of diagnostic relevance: cloudiness of the optical media, missing adherence, relevant diseases of the cornea and retina, existence of at least one of the following lab criterions at time point of study inclusion: creatinine = 90µmol/l, proteinuria = 300mg/d, protein creatinine ratio = 0,3 mg/mg or u-stick > 1+, ALT/AST > 40 IU/l resp. >0,67µkat/l, platelets < 150 x 10^9/l.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of pre-eclampsia (in accordance to ISSHP criterions) | — |
Secondary
| Measure | Time frame |
|---|---|
| Development of pregnancy induced arterial hypertension (in accordance to ISSHP criterions) or intrauterine growth restriction in accordance to the German guideline. | — |
Countries
Germany
Contacts
Public ContactJohannes Stubert
Universitätsfrauenklinik und Poliklinik am Klinikum Südstadt Rostock
Outcome results
None listed