Characterization of neural networks underlying motor tic formation and suppression

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00024834

Enrollment

Registered

2021-04-21

Start date

2021-10-27

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F95.1 F95.2

Interventions

Group 1: Patients with a tic disorder will be interviewed once and asked to perform computer-assisted tasks. During the course of the study, the following assessments will be administered: 1) variou

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: - Fluent in the German language - Age 18 to 65 years - For Patients: Chronic motor tic disorder (F95.1) or chronic motor and vocal tic disorder (F95.2) as main diagnosis according to the International Classification of Diseases 10 (ICD 10)

Exclusion criteria

Exclusion criteria: - Active suicidal or homicidal ideation within last 6 months - Current psychotic symptomatology - Active or recent substance abuse (except intake of cannabis-based substances, if consumed for treatment of tics and if they are paused 72 hours before the experiment) - Serious systemic medical disease that requires treatment - Clinically relevant neurological disorder of the central nervous system such as stroke, epilepsy, neoplasia - Mental retardation or other unstable psychiatric disorder that requires treatment - Active medication with benzodiazepine that cannot be paused for 72 hours - Withdrawal of consent

Design outcomes

Primary

Measure	Time frame
1) Modulation in the theta (4-8 Hz) and beta (15-30 Hz) frequency band will be investigated in cortical areas (DLPFC, ACC, PCC) for the effect of voluntary tic suppression.	—

Secondary

Measure	Time frame
1) Modulation in the theta (4-8 Hz) and beta (15-30 Hz) frequency bands will be examined in cortical areas (SMA, M1, Insula) for a relationship with urge sensation. 2) Differences in theta (4-8 Hz) and beta (15-30 Hz) frequency bands will be shown between blinks and blink tics primarily in areas of sensorimotor integration (SMA, insula). 3) Modulation of EEG signal during motor prediction task between patients and healthy controls will be expect in ACC.	—

Measure

Time frame

1) Modulation in the theta (4-8 Hz) and beta (15-30 Hz) frequency bands will be examined in cortical areas (SMA, M1, Insula) for a relationship with urge sensation. 2) Differences in theta (4-8 Hz) and beta (15-30 Hz) frequency bands will be shown between blinks and blink tics primarily in areas of sensorimotor integration (SMA, insula). 3) Modulation of EEG signal during motor prediction task between patients and healthy controls will be expect in ACC.

—

Countries

Germany

Contacts

Public ContactThomas Schüller

Klinik für Psychiatrie und Psychotherapie, Klinikum der Universität zu Köln

thomas.schueller@uk-koeln.de0221 478 98844

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026