Prospective, monocentric clinical study about the effect of a novel technique for mucus mobilization on lung function, mucus viscosity and diaphragmatic mobility in cystic fibrosis patients

Prospective, monocentric clinical study about the effect of a novel technique for mucus mobilization on lung function, mucus viscosity and diaphragmatic mobility in cystic fibrosis patients - SekMobi-1

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00024819

Enrollment

Registered

2021-04-08

Start date

2020-09-16

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E84.0

Interventions

Group 1: Comparison of lung functions parameters and diaphragmatic mobility before and after mucus mobilisation with the device with the CR-number 30483. 1) sampling of expectorated mucus and determin

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: diagnosed cystic fibrosis

Exclusion criteria

Exclusion criteria: - acute infection - reduced general condition - massive hemoptysis within the last 4 weeks - pneumothorax within the last 6 weeks - uncontrolled asthmatic symptoms - unstable cardiovascular disease - unstable pulmonary situation with dyspnea - pregnancy

Design outcomes

Primary

Measure	Time frame
lung function parameters (FEV1, MEF25, MEF50, MEF75), measured by spirometry	—

Secondary

Measure	Time frame
1. Diaphragmatic mobility before and after the intervention; sonographic measurement of the diaphragmatic excursion and speed of the diaphragmatic movement of in- and expiration 2. Viscosity and DNA-concentration of the expectorated mucus before and after the intervention; measurement via FRAP (fluorescence recovery after Photobleaching) and dye based determination of DNA-concentration	—

Countries

Germany

Contacts

Public ContactDorit Fabricius

Ulm University Medical Center

dorit.fabricius@uniklinik-ulm.de0731/50057376

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026