F32 R73
Conditions
Interventions
Group 1: A functional magnetic resonance imaging (fMRI) is conducted on the subjects following intranasal insulin administration, both during rest and while performing a reward task and an emotional s
Sponsors
Neurometabolic circuitry Lab Department for Psychiatry, Psychosomatics and Psychotherapy Goethe University Frankfurt
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for controls: • Age:18-65 years • Ability to give consent Inclusion criteria for diabetic patients: • Age:18-65 years • Presence of a prediabetic or diabetic condition according to the American Diabetes Association (American Diabetes, 2020): • Ability to give informed consent - only Metformin as medication allowed Inclusion criteria for depressive patients: • Age:18-65 years • Presence of a depressive Episode, both first episode or an an episode in the context of a know recurrent depressive disorder with or without psychotic symptoms (according to ICD 10: F32.0, F32.1, F32.2, F32.3, F33.2, F33.3). • Ability to give consent
Exclusion criteria
Exclusion criteria: Exclusion criteria for controls: • History of - Diabetes mellitus or prediabetic condition - Psychiatric diseases - neurological, autoimmune, rheumatological, neoplastic, dermatological or metabolic disorders - acute infection • Pregnancy and lactation • Regular medication with insulin, insulin-mimetika, antitiabetic drugs • Weight loss > 5 % of body weight within the last three months Exclusion criteria for patients: • History of - psychiatric disease: dementia, bipolar disorder, schizophrenic psychosis, substance abuse disorder - neurological, autoimmune, rheumatological, neoplastic, dermatological or other metabolic disorders than diabetes mellitus or prediabetes - skin disseases - acute infection • Medication with insulin/insulin-mimetika or glucocorticoids • Clearly organic or substance-induced cause of depression • Pregnancy and nursing • Weight loss > 5 % of body weight within the last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in fMRI brain activity during the performance of the reward task and the emotional stimulus processing task, following intranasal insulin administration, is investigated in depressed patients and patients with insulin resistance, compared to the activity after intranasal placebo administration, in comparison to the control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| The alteration in reward learning and stress perception is investigated in depressed patients and patients with insulin resistance, compared to control subjects. | — |
Countries
Germany
Contacts
Public ContactSharmili Edwin Thanarajah
Neurometabolic circuitry Lab Department for Psychiatry, Psychosomatics and Psychotherapy Goethe University Frankfurt
Outcome results
None listed