Role of the Human Microbiome and covid-19 disease in hospital Acquired and Ventilator Associated pneumonia in critically ill patients

Role of the Human Microbiome and covid-19 disease in hospital Acquired and Ventilator Associated pneumonia in critically ill patients - HAI

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00024777

Enrollment

1200

Registered

2021-04-12

Start date

2021-06-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

U69.01

Interventions

Group 1: - Weekly swabbing of major microbiome sites (nares, oral, skin, gut) - Isolates obtained from point of infection will be provided by the medical microbiology unit of the University Hospital (

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Age = 18 years - signed consent - icu treatment - rise in SOFA Score = 2 points - expected length of icu treatment > 72 h

Exclusion criteria

Exclusion criteria: - age < 18 years - pregnant or breastfeeding women - antibiotical therapy within last 30 days - antibiotcal therapy for more than 24 h within index hospitalization - transfer from icu within 72 h likely - best supportive care / withhold or withdrawal of therapy - death deemed likely or inevitable within next 72 h - patients, that already participated in this study

Design outcomes

Primary

Measure	Time frame
genetic diversity / specific mutations in pathogen species	—

Secondary

Measure	Time frame
days on ventilator, rate of organ dysfunction (acute kidney injury, shock) icu mortality	—

Countries

Germany

Contacts

Public ContactBastian Pasieka

Universitätsklinikum LeipzigInterdisziplinäre Internistische Intensivmedizin

Pasieka@medizin.uni-leipzig.de0341/9712378

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026