other: depressive symptoms of bipolar disorder, negative symptoms of schizophrenia Healthy volunteers F32
Conditions
Interventions
Group 1: Patients undergoing NTBS treatment (TMS, tDCS) at our department will be assessed with structured questionnaires, including e.g. the MADRS and BDI questionnaires, and neuroimaging
Group 2: He
Sponsors
Department of Psychiatry and Psychotherapy, LMU Hospital Munich
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - Indication for NTBS treatment for a depressive episode as assessed by the clinical evaluation - Patient preference for NTBS treatment - Capable and willing to provide informed consent.
Exclusion criteria
Exclusion criteria: - Individuals with a substance abuse disorder or substance dependence (except nicotine, caffeine) in the last 6 months - Individuals at suicidal risk - Any relevant instable medical condition (e.g. acute, unstable cardiac disease) - Individuals diagnosed with a significant neurological disorder or insult including, but not limited to: o Increased intracranial pressure o Space occupying brain lesion o History of cerebrovascular accident o Transient ischemic attack within two years o Cerebral aneurysm o Huntington’s chorea o Multiple sclerosis o Epilepsy - Individuals with a history of severe traumatic brain injury or status post brain/heart surgery - In general, individuals with any history of seizures - Individuals with significant anatomical abnormalities as seen on cerebral MRI - Individuals with non-removable, ferromagnetic implants/material in proximity to application site (e.g. cochlear implant, implanted neurostimulators, nails, clips, etc.) or treatment-relevant ferromagnetic implants in other body parts (e.g. cardiac pacemaker) - For tDCS specifically – severe skin disorders (e.g. psoriasis vulgaris) in proximity to application site
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression severity assessed by MADRS at the end of (acute) treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| BDI, HDRS, other clinical scales, cognitive performance, neuroimaging parameters | — |
Countries
Germany
Contacts
Public ContactLucia Bulubas
Department of Psychiatry and Psychotherapy, LMU Hospital Munich
Outcome results
None listed