I35.8 N17.2
Conditions
Interventions
Group 1: 1. interventional aortic valve replacement via catheter through the inguinal artery (transfemoral transcatheter aortic valve implantation.
Group 2: 2. Minimally invasive via intercostal incis
Sponsors
Klinik für AnästhesiologieUniversitätsklinikum Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with aortic valve replacement: - Written informed consent by the study participant - Age = 18 years - Planned aortic valve replacement in the cardiology or cardiosurgery clinic of Heidelberg University Hospital Healthy subjects: - Written informed consent by the study participant - Age = 18 years
Exclusion criteria
Exclusion criteria: Exclusion criteria common to all study groups: - Failure to meet inclusion criteria. - Infectious viral diseases (HBV, HCV, HIV, COVID-19) or unknown COVID-19 status. - Refusal to participate in the study - Pre-existing severe renal insufficiency with a glomerular (GFR) <15 ml/min/m2 or need for dialysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hyperspectral measurement of various microcirculatory parameters (tissue oxygenation, near-infrared perfusion index, tissue hemoglobin index, tissue water index) on the hand before and after aortic valve replacement | — |
Secondary
| Measure | Time frame |
|---|---|
| -Kidney function/regeneration/injury markers such as creatinine, stathmin and PCNA, albumin, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl glucosaminidase (NAG). - Isolation and profiling of exosomes from serum and urine (using lineage- or cell lineage-specific markers) including evaluation as a potential effector in co-culture with renal cells | — |
Countries
Germany
Contacts
Public ContactDania Fischer
Klinik für AnästhesiologieUniversitätsklinikum Heidelberg
Outcome results
None listed