Prevalence of early retinal vasculoneurodegenerative alterations in children and adolescents with Type 1 Diabetes

Prevalence of early retinal vasculoneurodegenerative alterations in children and adolescents with Type 1 Diabetes - RetinaT1D

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00024728

Enrollment

350

Registered

2021-03-15

Start date

2027-04-20

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 1 Diabetes mellitus H35.0

Interventions

Group 1: Patients with type 1 diabetes The following non-invasive examinations are carried out on patients and healthy controls via the study center of the University Clinic for Ophthalmology (level

Eligibility

Sex/Gender

All

Age

10 Years to 18 Years

Inclusion criteria

Inclusion criteria: Type 1 Diabetes (T1D), T1D, for a duration 2 years, Age 10-18 years, at time of T1D onset living in Vienna

Exclusion criteria

Exclusion criteria: severe visual impariement light sensitive epilepsy hyperopia/myopia ±5.5 Dioptries

Design outcomes

Primary

Measure	Time frame
Diabetic retinopathy Ophthalmological findings through manual evaluation of the Fundus photography and funduscopy - (categorical): - Retinopathy (visually threatening, moderate, mild - in summary) - no retinopathy This is collected as part of study visits 1, study visits 2 (12 months later) and study visits 3 (24 months later).	—

Secondary

Measure	Time frame
Secondary target parameters • Central retinal thickness • Morphological biomarkers in OCT (fluid, microaneurysms, detailed analysis of the thickness of the individual retinal layers) and OCT-A (retinal ischemia and vascular density in different retinal layers) • photoreceptors (number) • Central vessels (measurement of the lumen and wall thickness) • Diabetic retinopathy through automated evaluation of the IDxDR fundus photo (categorical): -- Visually threatening retinopathy = macular edema, severe non-proliferative or proliferative retinopathy -- Moderate retinopathy -- Mild retinopathy = non-proliferative retinopathy or no retinopathy	—

Measure

Time frame

Secondary target parameters • Central retinal thickness • Morphological biomarkers in OCT (fluid, microaneurysms, detailed analysis of the thickness of the individual retinal layers) and OCT-A (retinal ischemia and vascular density in different retinal layers) • photoreceptors (number) • Central vessels (measurement of the lumen and wall thickness) • Diabetic retinopathy through automated evaluation of the IDxDR fundus photo (categorical): -- Visually threatening retinopathy = macular edema, severe non-proliferative or proliferative retinopathy -- Moderate retinopathy -- Mild retinopathy = non-proliferative retinopathy or no retinopathy

—

Countries

Austria

Contacts

Public ContactKatrin Nagl

Medizinische Universtität WienUniversitätsklinik für Kinder- und Jugendheilkunde

katrin.nagl@meduniwien.ac.at+4314040031880

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 27, 2026