Investigation of endometriosis-symptoms and tumor marker CA 125 in women with Von Willebrand disease

Investigation of endometriosis-symptoms and tumor marker CA 125 in women with Von Willebrand disease - CA125_VWS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00024676

Enrollment

104

Registered

2021-12-29

Start date

2021-10-07

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

D68.00

Interventions

Group 1: Single blood collection (5ml) in female VWD-patients: Determination of of CA 125 serum level. Gynecological anamnesis by a questionnaire.

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: -female patients at least 18 years who have not reached menopause -confirmed von Willebrand disease (every type, every severity) -signed consent

Exclusion criteria

Exclusion criteria: -male patients -female patients < 18 years or post-menopausal -Von Willebrand disease not confirmed -no signed consent

Design outcomes

Primary

Measure	Time frame
Single blood sampling (5 ml): determination of tumor-marker CA 125 in serum (normally <35 U/ml)	—

Secondary

Measure	Time frame
Survey of different gynecological parameters by patient questionnaire: menstrual-complaints (first menstruation, duration, regularity, bleeding-duration/-intensity, pain), dysmenorrhea, menorrhagia, endometriosis, cervical-cancer, ovarian-cancer in first-degree-relatives, suspected endometriosis or diagnosed endometriosis, other gynecological surgeries, pregnancies (number and outcome: births, miscarriages, abortions, current pregnancy?), contraception (hormone medication?, impact on pain?), other diseases. Additional documentation of the following data: Age, known cancer, current infections, ISTH BAT-Score (Rodeghiero et al., 2010), vWD-Type, current vWF-parameters, current treatment of vWD	—

Measure

Time frame

Survey of different gynecological parameters by patient questionnaire: menstrual-complaints (first menstruation, duration, regularity, bleeding-duration/-intensity, pain), dysmenorrhea, menorrhagia, endometriosis, cervical-cancer, ovarian-cancer in first-degree-relatives, suspected endometriosis or diagnosed endometriosis, other gynecological surgeries, pregnancies (number and outcome: births, miscarriages, abortions, current pregnancy?), contraception (hormone medication?, impact on pain?), other diseases. Additional documentation of the following data: Age, known cancer, current infections, ISTH BAT-Score (Rodeghiero et al., 2010), vWD-Type, current vWF-parameters, current treatment of vWD

—

Countries

Germany

Contacts

Public ContactWolfgang Miesbach

Hämophiliezentrum, Institut für Transfusionsmedizin, Medizinische Klinik III, Goethe Universitätsklinikum

wolfgang.miesbach@kgu.de06963015051

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026