F33 F32 F31 F42
Conditions
Interventions
Group 1: patients with difficult to treat depression under treatment with deep brain stimulation (DBS) of the medial superolateral forebrain bundle (slMFB)
Group 2: patients with severe obsessive comp
Sponsors
Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Able to give informed consent to study participation. in addition: Group 1) and 2) - Treatment with DBS of the slMFB by the Department of Interventional Biological Psychiatry at the Medical Center - University of Freiburg Group 3) - pre-diagnosed affective disorder (unipolar or bipolar) - currently undergoing psychiatric or psychotherapeutic treatment Group 4) - Pre-diagnosed obsessive-compulsive disorder (predominantly compulsive acts, predominantly obsessive thoughts or mixed) - currently undergoing psychiatric or psychotherapeutic treatment
Exclusion criteria
Exclusion criteria: - acute suicidality - non-affective psychotic symptoms in the past or present - physical limitations that affect the execution of the test - legal guardianship of the study participant also Group 5) - currently undergoing psychotherapy or psychiatric treatment - current psychiatric illness - psychotic illness in the past substance abuse (except nicotine)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aspects of reward processing and emotion recognition will be assessed in a single study appointment per participant/patient. Patients from arm1 and arm2 will perform the computerized tests twice. Once with deep brain stimulation turned on and once with deep brain stimulation turned off, whereby the sequence (switched on/off) will be balanced over patients. Aspects of reward processing measured by: - Mannheim Reward Task (Kirsch et al., 2003; Plichta et al., 2012) -> reaction times -> money winnings achieved - WebSurfTask (risk version) (Abram et al., 2019) -> reaction times -> maximum tolerated waiting times -> behavior pattern over time (decision behavior) -> Stimulus preference - Reinforcement Sensitivity Theory - Personality Questionnaire (Pughnaghi et al., 2018) -> Characteristics on the different scales | — |
Secondary
| Measure | Time frame |
|---|---|
| - Severity of depressive symptoms recorded by -> Sum scores of the external assessment using MADRS (Montgomery & Åsberg, 1979), HAMD (Hamilton, 1960) -> Sum score of the self-assessment in the BDI-II (Hautzinger et al., 2006) - Severity of obsessive-compulsive symptoms recorded by -> Sum score of the external assessment using YBOCS (Hand et al., 1991) -> Sum score of the self-assessment using OCI-R (Gönner et al., 2007) - DBS parameters (only for groups with DBS) --> Device, model and battery type, the current daily stimulation parameters and the current impedances | — |
Countries
Germany
Contacts
Public ContactDora Meyer-Doll
Universitätsklinikum Freiburg
Outcome results
None listed