E24.9 G73.5
Conditions
Interventions
Group 1: Early intervention with individual physical training from 4 weeks after baseline/surgery to 13 months after baseline/surgery
Group 2: Standard follow-up in the first 7 months after baseline/s
Sponsors
Medizinische Klinik und Poliklinik IV, LMU Klinikum München
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Cushing's syndrome: - path. Dexamethasone inhibition test - path. 23 o'clock salivary cortisol level - path. 24h-collection urine cortisol - planned surgery - Confirmed subtype: adrenal, pituitary or ectopic Cushing's syndrome in long-term remission: - Successfully treated Cushing's syndrome - Persisting functional impairment
Exclusion criteria
Exclusion criteria: - Age under 18 years or over 65 years - Contraindication to surgery - Existing pregnancy - Chronic general illness - Alcohol or drug abuse - Physical limitation to participate in the exercise program - Participation in another interventional clinical trial - Life expectancy of less than one year - Myocardial infarction within the past 3 months - Cardiopulmonary instability or ischemia signs during exercise testing - Cytostatic therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grip strength after 6 month Intervention (at the time 7 months after baseline/Operation) | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle function, diastolic dysfunction, body composition and muscle mass, quality of life | — |
Countries
Germany
Contacts
Public ContactMartin Reincke
Medizinische Klinik und Poliklinik IV LMU Klinikum München
Outcome results
None listed