Effects of midazolam co-induction to general anesthesia

Effects of midazolam co-induction to general anesthesia - Midazolam co-induction to general anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

DRKS

Registry ID

DRKS00024564

Enrollment

102

Registered

2021-08-18

Start date

2018-07-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E89 R03

Interventions

Group 1: Placebo (0,9% NaCl), 1 ml i.v. (intravenous) 60 sec. prior to administering medications for induction to general anesthesia Group 2: Dormicum (midazolam), 0,03 mg/kg body weight i.v. 60 sec.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: This study will include patients, aged 18-65 years, ASA II and III status according to the classification of the American Society of Anesthesiologists, scheduled for laparoscopic cholecystectomy in the period 8:30-11:00 AM

Exclusion criteria

Exclusion criteria: Exclusion criteria are: patients with diabetes mellitus, patients on chronic benzodiazepine therapy, patients with chronic cardiac arrhythmias and patients who develop cardiac arrhythmia during procedure, patients with first measured arterial pressure higher than 180/105 mm Hg or lower than 100/60 mm Hg, conversion from laparoscopic to laparotomy procedure will exclude patients from study

Design outcomes

Primary

Measure	Time frame
To determine efects of midazolam coinduction to general anesthesia on mean arterial blood pressure and heart rate values (measured on anesthesia monitor by noninvasive methods). To determine effects of midazolam coinduction to general anesthesia on differences in blood glucose concentration during and after surgery. To determine effect of midazolam coinduction to general anesthesia on differences in blood cortisol concentration after surgery (Analysis of blood samples performed at Laboratory department of Sveucilišna klinicka bolnica Mostar).	—

Measure

Time frame

To determine efects of midazolam coinduction to general anesthesia on mean arterial blood pressure and heart rate values (measured on anesthesia monitor by noninvasive methods). To determine effects of midazolam coinduction to general anesthesia on differences in blood glucose concentration during and after surgery. To determine effect of midazolam coinduction to general anesthesia on differences in blood cortisol concentration after surgery (Analysis of blood samples performed at Laboratory department of Sveucilišna klinicka bolnica Mostar).

—

Secondary

Measure	Time frame
To examine effect of midazolam coinduction on the incidence of postoperative nausea and vomiting using a simple questionnaire To examine effect of midazolam coinduction on the level of postoperative anxiety using Zung Self-Rating Anxiety Scale	—

Countries

Bosnia & Herzegovina

Contacts

Public ContactMirko Mihalj

University Clinical Hospital Mostar, Department of anesthesia, reanimation and intensive care, Specialist of anesthesia nad reanimation

mirko.mihalj@skbm.ba+38763694351

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026