Multiple sclerosis G35.1 G35.2 G35.3
Conditions
Interventions
Group 1: Intervenion group: 6 weekly music therapeutic sessions of approximately 45 minutes. Lying 15 minutes on the Monochord, while the music therapists plays the instrument. Introductory ans closin
Sponsors
Universitätsspital Basel Neurologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Diagnosis of relapsing-remitting MS (RRMS) or progressive (primary or secondary) MS 2) age >18ys 3) EDSS score of = 6.5 4) Written consent for participation in the study. Background knowledge about music is not a prerequisite for study participation, but no exclusion criterium either.
Exclusion criteria
Exclusion criteria: 1) Reported or medically recorded diagnoses of current serious psychological disorders including acute and severe depression, suicidality and severe anxiety syndromes 2) Other currently life-threatening or severely disabling physical disorders 3) >2 MS relapses within the last year 4) MS relapse within the last 3 months before recruitment 5) MS immune modulating medication altered within the last 3 months 6) Symptomatic MS medication for depression, anxiety, fatigue, pain or cognition altered in the last 3 months 7) Pregnancy (due to many possible pregnancy-related/hormonal changes in our primary and secondary outcomes) 8) Inability to lie supine for 15 min 9) Severely compromised hearing (unless patient has sufficient hearing aid) 10) Severe numbness in both hands, MS related or due to other causes. Specifically vulnerable patient groups will not be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in anxiety as measured by the anxiety subscale of The Hospital anxiety and Depression Scale (HADS-A). Timepoints: Baseline, before the second, forth and sixth music-therapeutic session as well as at follow-up 8 weeks after study end. Hypothesis: Receptive music therapy with the Monochord can reduce anxiety by 2.5 points on the HADS-A. | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression: HADS, Subscale Depression (HADS-D); Fatigue: Modified Impact Scale (MFIS); Stress perception: Perceived Stress Questionnaire 20 (PSQ20); Quality of life: Short Form 36 (SF-36); Cognition: Symbol Digit Modality Test (SDMT); Thresholds for perception of pain, heat, cold, pressure and mechanical pain: Quantitative sensory testing (QST); Well-being: Pre-post-questionnaire before und after each session. All secondary endpoint will be measured at study start (baseline) and study end (study completion). HADS-D will be assessed additionally before the second, fourth and sixth session and at follow-up. | — |
Countries
Switzerland
Contacts
Public ContactAthina Papadopoulou
Universitätsspital Basel Neurologie
Outcome results
None listed