I63
Conditions
Interventions
Group 1: In stroke patients with residual hand motor function (MRC>1) the following parameters are tested within 7 days after hospitalization and after 4 months: TMS-EEG and online-rTMS-intereference
Sponsors
Uniklinik Köln
Eligibility
Sex/Gender
All
Age
20 Years to 95 Years
Inclusion criteria
Inclusion criteria: written consent, ischaemic stroke, hemiparesis with impaired unilateral hand-motor function
Exclusion criteria
Exclusion criteria: Subjects who are legally detained in an official institute (§20 MPG), participation in a clinical trial within the last 12 weeks, electronic implants or ferromagnetic implants located in the head, neck or thorax (eg, clips, intracranial shunt, artificial heart valve, pacemaker), medication pump (eg, insulin pump), metal splinters in eye or head, pregnancy/breastfeeding, severe neurodegenerative disease, severe neuroinflammatory disease, history of seizures/epilepsy, physical addiction to alcohol, medication or drugs (excluded: nicotine), insufficient compliance, present or past malignant tumour involving the central nervous system, severe psychiatric disease, clinically manifest bilateral hemiparesis or infarcts in the primary motor cortex or along the corticospinal tract in the hemisphere ipsilateral to the hemiparesis, pre-existing cerebral infarctions with hemiparesis or pre-existing cerebral infarctions in the primary motor cortex or along the corticospinal tract, excluding microvascular changes (eg, clinically asymptomatic lacunae 20, blood glucose imbalances resistant to treatment (300 mg/dL), elevated blood pressure resistant to treatment (>185/110 mm Hg), systemic thrombolysis using alteplase or thrombectomy within the last 24 hours before enrolment in study, medication with benzodiazepines, high-potency antipsychotics or tricyclic antidepressants before hospitalisation or long-term during hospitalisation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alterations in TMS-EEG and online-rTMS response patterns in stroke patients. Testing is performed twice: within 7 days after hospitalization and after 4 months. neuronavigated TMS-EEG: M1: ipsilesionel und contralesionel PMd: ipsilesionel und contralesionel online-rTMS - interference: identical positions as for TMS-EEG | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of the extend of TMS-EEG alterations and hand function.Testing is performed twice: within 7 days after hospitalization and after 4 months. behavioural parameters: NIH Stroke Scale (NIHSS) Fugl-Meyer Upper Extremity (FM-UE) score modified Rankin Scale (mRS) Action Research Arm Test (ARAT) Vigorimeter grip force finger tapping speed Handedness Questionnaire Purdue Pegboard test Jebsen-Taylor Hand Function Test (JTT) Timed-Up-and-Go test (TUG) neuropsychological testing: Go/Nogo-Task Cologne Apraxia Screening Kölner neuropsychologisches Screening für Schlaganfallpatienten (KöpSS) Aphasie Check List (short version, ACL-K) Beck Depression Inventory (BDI-II)/ Montgomery-Asberg Depression Rating Scale (MADRS) DemTect Trail making Test (TMT) EuroQol5 (EQ-5D) Level/years of education neuroimaging sequences: high resolution DWI image resting-state fMRI sequence diffusion MRI for DTI 3D-T1 image T2 image FLAIR qMT | — |
Countries
Germany
Contacts
Public ContactVeronika Wunderle
Klinik für Neurologie, Uniklinik Köln
Outcome results
None listed