Residual lung damage after COVID-19 pneumonia
Conditions
Interventions
Group 1: Patients after hospitalization or complications from severe COVID-19 pneumonia are subject to one to two years of follow-up using morphologic and functional MRI. The standardized MRI protocol
Sponsors
Klinik für Diagnostische und interventionelle RadiologieUniversitätsklinikum Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: a) Patients after severe course of and/or hospitalization for COVID-19 pneumonia b) Patients presenting with lung function impairment developing after COVID-19 pneumonia c) Patients after COVID-19 pneumonia with clinical indications for imaging (typically CT)
Exclusion criteria
Exclusion criteria: a) missing informed consent b) contra-indications for MRI (pacemakers, implants, claustrophobia) c) contra-indications for the contrast material (renal dysfunction, prior adverse reactions) - in these cases the MRI protocol can be limited to the non-ce sequences.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the quality and prevalence of morphologic and functional lung damage after severe COVID-19 pneumonia over up to two years using lung MRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Establishment of MRI as radiation-free method for the follow-up after severe virus-pneumonia 2. Optimization of the MRI protocol for this purpose 3. Detection of appropriate imaging-based biomarkers (lung perfusion, lesion scores) and combinations with clinical biomarkers 4. To refine the procedures and to gain the necessary experience for the set-up a large multi center-trial, if needed | — |
Countries
Germany
Contacts
Public ContactOyunbileg v. Stackelberg
Klinik für Diagnostische und interventionelle RadiologieUniversitätsklinikum Heidelberg
Outcome results
None listed