Collection of Biospecimen and Analysis of the Progression of different Subtypes of Aortic Stenosis

Conditions

I35.0

Lange T, Beuthner BE, Schulz A, Backhaus SJ, Evertz R, Rigorth KR, Toischer K, Kowallick JT, Hasenfuss G, Puls M, Schuster A.

2025-02-01

10.1148/ryct.230380

Epicardial adipose tissue as an independent predictor of long-term outcome in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement

Alexander Schulz, Bo Eric Beuthner, Zoé M. Böttiger, Svante Gersch, Torben Lange et al. (11 authors)

Clinical Research in Cardiology2024-02-0711 citations

10.1007/s00392-024-02387-5

Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study

Torben Lange, SÃ¶ren J. Backhaus, Bo Eric Beuthner, Rodi Topci, Karl-Rudolf Rigorth et al. (15 authors)

Journal of Cardiovascular Magnetic Resonance2022-01-0124 citations

10.1186/s12968-022-00874-0

Interventions

Group 1: Preprocedural: -Minnesota Living with Heart Failure Questionnaire - 6-Minute Walking Test - Blood sample - Urine sample - Rectal swab - MRI - CT (clinical routine) - TTE und TEE (clinical rou

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Severe aortic stenosis or regurgitation that is scheduled for replacement therapy - Informed consent

Exclusion criteria

Exclusion criteria: - Severe coagulopathy - Documented left-ventricular thrombus - Missing informed consent - Non-compliant patients - Supervised patients

Design outcomes

Primary

Measure	Time frame
Primary aim of this study is to improve the understandning of molecular mechanisms underlying the development and progression of severe aortic stenosis.	—

Secondary

Measure	Time frame
Knowledge of mechanisms underlying the development and progression of severe aortic stenosis will yield improved understanding of mechanisms leading to heart failure.	—

Countries

Germany

Outcome results

None listed