Healthy volunteers
Conditions
Interventions
Group 1: Non-smokers (Age between 18-50 years, n=35).
Anodal HD-tDCS stimulation at F6 (EEG 10-20 system, 1,5 mA for 20 minutes).
Return electrode at T8, C4, Fz & FPz (EEG 10-20 system).
Resting s
Sponsors
Universitätsklinikum der RWTH Aachen, Medizinische Fakultät
Eligibility
Sex/Gender
Male
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Smoker (>10 cigarettes a day), Non-Smoker, right-handed, fluent in the german language
Exclusion criteria
Exclusion criteria: Inclusion Criteria are not fulfilled, Exclusion criteria for MRI research are positive, mental illness according to SKID 5, taking any form of illegal substances
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| *Confirmatory* Difference in stop-signal reaction time before and after stimulation. Influence of HD-tDCS application, nicotine and trait impulsivity (BIS11). | — |
Secondary
| Measure | Time frame |
|---|---|
| *Exploratory* Difference of resting-state functional connectivity before-, during- and after HD-tDCS application between groups and in consideration of a potential improvement in response inhibition. Influence of grey-matter volume of the inferior frontal gyrus on the effectivity of HD-tDCS on response inhibtion. Simulation of the electric field that is induced by the HD-tDCS application (Using a T1 and a T2 weighted MRI measurement, the electric field that is created can be individually modelled for every participant.) CO2 measurement of smokers. SSRT: Reaction time, percent of correctly inhibited trials, percentage of errors (clicking the wrong button) Different Questionnaires (UPPS, SKID, PANAS, Audit, RPQ, AQ, SPSRQ) Neuropsychological tests (WST, TMT-A, TMT-B, digit span forward and backward) | — |
Countries
Germany
Contacts
Public ContactDario Müller
Universitätsklinikum der RWTH Aachen
Outcome results
None listed