D63 K05 D64.8
Conditions
Interventions
Group 1: Patients (n=15) with clinically diagnosed generalized periodontitis.
Study participants will undergo a clinical oral examination (c.a 1h). In the course of this examination, a sample of the
Sponsors
Poliklinik für Zahnerhaltung und Parodontologie
Eligibility
Sex/Gender
All
Age
70 Years to No maximum
Inclusion criteria
Inclusion criteria: Ability to give independent consent Sufficient knowledge of German Absence of exclusion criteria
Exclusion criteria
Exclusion criteria: patients with acute and chronic inflammation (CRP >5mg/dl) Patients with active tumor disease requiring treatment, infection requiring treatment, actual antibiotic treatment chronic inflammatory disease such as rheumatoid arthritis, chronic inflammatory bowel disease osteomyelitis previous (within 2 weeks) apoplectic insult with lysis treatment glomerular filtration rate <30 ml/min dialysis requirement or coronary heart disease requiring intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral health screening (PBI, Quigley-Hein index, PSI/CPITN) and collection of a sulcus sample (aMMP8 and calprotectin) are performed on the examination date for geriatric patients. These data will be statistically analyzed with the routinely recorded blood parameters (leukocytes, erythrocytes, hemoglobin, hematocrit, RDW platelets, MCV, MCHC, MCH, CRP, transferrin saturation, ferritin, C-reactive protein, transferrin, cobalamin (VitB12), and folic acid) and geriatric parameters from the patient record (Barthel index, current medication, principal diagnosis, and comorbidities). The aim of the study is to investigate whether the highly prevalent chronic periodontitis in the group of geriatric patients contributes to chronic inflammatory anemia and thus could serve as a risk indicator. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Sulcus fluid calprotectin and aMMP8 levels correlate with each other and with laboratory values of inflammatory anemia. - To assess whether the degree of periodontitis is associated with an increase in the RDW value (red cell distribution width). - Assess whether the degree of periodontitis is associated with MCV heterogeneity. - Assess whether decreased MCV and increased RDW are associated with periodontitis. | — |
Countries
Germany
Contacts
Public ContactGreta Barbe
Poliklinik für Zahnerhaltung und Parodontologie
Outcome results
None listed