G35 I67.10
Conditions
Interventions
Group 1: Modern MRI acceleration technique
Group 2: Conventional acceleration technology
Sponsors
Institut für Radiologie und NeuroradiologieEvangelisches Krankenhaus OldenburgUniversitätsmedizin Oldenburg
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: General: persons with a minimum age of 18 years who are able to give informed consent Subproject 1 and 2, Step 1: Healthy Volunteers Subproject 1, Step 2: Patients with multiple sclerosis: Diagnosis of multiple sclerosis after the last revision (Thompson et al., Lancet Neurology 2018) of the McDonald's diagnostic criteria for multiple sclerosis or high clinical suspicion of MS with an appropriate clinical syndrome with at least 2 known T2-hyperintense lesions Subproject 2, Step 2: Patients with untreated intracranial aneurysms: diagnosis of one or more intracranial aneurysms, of which at least one is untreated at the time of the MRI scan; additionally treated aneurysms (for example by means of clipping, coiling, stenting or with flow-diverters) provided that these don't represent a contraindication for an MRI scan
Exclusion criteria
Exclusion criteria: General: general contraindications for MRI, for example implants such as non-conditional MR-suitable pacemaker or auto-defibrillator, implanted neural stimulator, ocular metal foreign bodies (e.g. metal shards). Conditions that could hinder the conduct of the study (e.B. morbid obesity, pronounced claustrophobia), existing unnecessary risks (pregnancy, surgery of an unsafe nature). Subproject 1 and 2, Step 1: Known serious diseases of the central nervous system Subproject 1, Step 2: Known serious diseases of the central nervous system (except MS in the patient group) Subproject 2, Step 2: Known serious diseases of the central nervous system (except intracranial aneurysms in the patient group) Note: neurovascular implants (aneurysm clips, coils, stents, flow diverters) are permitted when devices are classified as "MR-safe" or "conditionally MR-safe" if compliance with the required (i.e. manufacturer-recommended) examination conditions is guaranteed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subproject 1): Diagnostic accuracy in MS lesion detection. Detection rate of the optimized advanced technology compared to conventional reference technology. Subproject 2): Overall performance in aneurysm detection. Blinded assessment by two (neuro-)radiologists with different experience (numerical rating scale) compared to conventional technology. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time reduction, imaging parameters after optimization, various parameters for image quality. | — |
Countries
Germany
Contacts
Public ContactChristian Mathys
Institut für Radiologie und NeuroradiologieEvangelisches Krankenhaus OldenburgUniversitätsmedizin Oldenburg
Outcome results
None listed