L40 M07.3
Conditions
Interventions
Group 1: Psoriasis (optoacoustic and sonographic assessment)
Group 2: Psoriatic-Arthritis (optoacoustic and sonographic assessment)
Group 3: Healthy control (optoacoustic and sonographic assessment)
Sponsors
Universitätsklinikum Erlangen
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: - Adult male or female patients capable of giving consent - Age 18 - 80 years - Present informed consent to participate in the study. - Group 1 PsA o Diagnosis of PsO (clinical and/or histological) o Diagnosis of PsA according to CASPAR criteria - Group 2 PsO o Diagnosis of PsO (clinical and/or histological)
Exclusion criteria
Exclusion criteria: - Pregnancy - Heavy physical activity - Other previous musculoskeletal disease (such as rheumatoid arthritis, osteoarthritis) - Tumor disease, diabetes mellitus, cardiovascular disease, chronic kidney, gastrointestinal, or liver disease - Group 1 PsA o Pre-treatment or ongoing therapy with bDMARD and/or tsDMARD. - Group 2 PsO o Diagnosis/family history of rheumatic disease. o tendon pain, joint swelling o Pre-treatment or ongoing therapy with bDMARD and/or tsDMARD. - Group 3 Healthy individuals o diagnosis/family history of rheumatic disease o Diagnosis of PsO/PsA o tendon pain, joint swelling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification and comparison of structural and biochemical patterns (optoacoustic spectra providing MSOT values by spectral unmixing) in the imaging of the enthesial complex of patients with psoriatic arthritis and psoriasis and healthy volunteers by MSOT. | — |
Secondary
| Measure | Time frame |
|---|---|
| - To compare quantitative biochemical imaging of individual structures of the enthesial complex (tendons, ligaments, bursae, tendon attachments) on MSOT and corresponding ultrasound findings in clinically manifest vs. arthrosonographically detected enthesitis. - Identify quantitative biochemical changes associated with individual enthesitis-defining ultrasound findings (e.g., tendon thickening, erosions, power Doppler signal, bursitis). | — |
Countries
Germany
Contacts
Public ContactDavid Simon
Universitätsklinikum Erlangen
Outcome results
None listed