N17
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult patients undergoing cardiac surgery with CPB 2. Age between 18-90 years 3. Written informed consent
Exclusion criteria
Exclusion criteria: 1. Preexisting AKI (stage 1 and higher) 2. Patients with cardiac assist devices (ECMO, LVAD, RVAD, IABP) 3. Pregnancy, breastfeeding 4. Known (Glomerulo-) Nephritis, interstitial nephritis or vasculitis 5. Chronic kidney disease (CKD) with eGFR < 20 ml/min/1.73m2 6. Dialysis dependent CKD 7. Prior kidney transplant within the last 12 months 8. Persons held in an institution by legal or official order 9. Persons with any kind of dependency on the investigator or employees by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the adherence to the preventive care bundle according to the KDIGO guidelines in patients undergoing cardiac surgery with cardiopulmonary bypass | — |
Secondary
| Measure | Time frame |
|---|---|
| - occurrence of AKI within 72 hours after cardiac surgery - severity stage of AKI within 72 hours after cardiac surgery - use and duration of renal replacement therapy (RRT) - length of ICU stay - length of hospital stay - MAKE30 (combined endpoint consisting of persistent renal dysfunction (defined as serum creatinine = 1.5-times baseline), RRT and mortality) at day 30) | — |
Countries
Germany, Russia, Spain
Contacts
Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie, Universitätsklinik Münster