Q34.8 E84.0
Conditions
Interventions
Group 1: Blood, sputum and urine samples are taken from PCD and CF patients after at least 4 hours of fasting. All patients receive an analysis of lung function and a measurement of exhalative and nas
Sponsors
St. Josef-Hospital
Eligibility
Sex/Gender
All
Age
10 Years to No maximum
Inclusion criteria
Inclusion criteria: PCD patients: - Confirmed diagnosis of PCD according to the current diagnostic standard (at least 2 pathological findings typical of PCDs in different cilia examination methods, or 3 congruent abnormal results in 1 cilia examination technique, obtained from different samples, or proving PCD molecular genetics) - Age> = 10 years - Consent to study participation CF patients: - Patients with a confirmed diagnosis of CF according to current diagnostic criteria (2x positive sweat test, positive CF molecular genetics and / or CF-typical CFTR dysfunction in CF electrophysiology (ICM or nPD)) - Age> = 10 years - Consent to study participation Healthy controls: - Free from chronic respiratory diseases (such as asthma, bronchiectasis, etc.), free from acute infectious or inflammatory conditions (infections, trauma, fever), free from any chronic underlying disease with a potential inflammatory reaction / component - Age> = 10 years - Consent to study participation
Exclusion criteria
Exclusion criteria: - special diet in the last 2 weeks before the examination - consumption of canned fish the day before - for PCD and CF patients: acute pulmonary exacerbation according to modified Fuchs criteria - for healthy controls: acute infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of asymmetric dimethylarginine, arginine and NO metabolites in sputum of PCD patients compared to healthy controls and CF patients | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentration of arginine and asymmetric dimethylarginine in plasma and urine from PCD patients compared to CF patients and healthy controls. | — |
Countries
Germany
Contacts
Public ContactAnne Schlegtendal
Klinik für Kinder- und Jugendmedizin - Katholisches Klinikum Bochum
Outcome results
None listed