U07.1
Conditions
Interventions
Group 1: Patients after Kidney transplantation
5 blood samples each to measure the following parameters.
1. Baseline:
o IQuantiFERON SARS-CoV-2 RUO
o Quantitative determination of the anti-Sars-CoV2
Sponsors
Universitätsklinikum Köln
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients after kidney transplantation: - All patients over the age of 16 who are regularly treated in our outpatient clinics - Present written declaration of consent. Patients end stage kidney disease: - All patients who are preparing for a kidney transplant at our center. The minimum age is set at 16 years. - Present written declaration of consent. - Controll group: Present written declaration of consent.
Exclusion criteria
Exclusion criteria: - Persons who are in a dependent / working relationship with the examiners, in particular employees of the clinics and institutes involved - Current infection with SARS-CoV2 (positive PCR result) - Inability to consent, e.g. due to language barriers or mental illness - Placement in an institution based on a judicial or administrative order - Controll group: people who suffer from chronic kidney disease chronic immunosuppression
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| · Differences of the cellular and humoral immunity against SARS-CoV2 in the KTx group compared to the two control groups · Does the cellular and humoral immunity correlate with the frequency of SARS-CoV2 infections? | — |
Secondary
| Measure | Time frame |
|---|---|
| · Differences between living donation and post mortem donation? · Group differences between patients before and after kidney transplantation · Influence of immunosuppressants on the cellular and humoral immune response · Influence of relevant events during the follow-up (e.g. vaccination, changes in immunosuppression) on cellular and humoral immunity | — |
Countries
Germany
Contacts
Public ContactPatrick Affeldt
Universitätsklinikum Köln
Outcome results
None listed