C71
Conditions
Interventions
Group 1: Patients with a preoeprative SMA mapping: For the mapping, TMS bursts (repetitive navigated TMS at 20Hz, 120% RMT, 5 seconds per burst) will be applied over the suspected SMA region while pat
Sponsors
Klinik für Neurochirurgie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients: Suspected tumor after cranial imaging; localisation within supplementary motor area; age > 18 years; written informed consent Healthy subjects: age > 18 years; written informed consent
Exclusion criteria
Exclusion criteria: Patients: Contraindications for receiving an MRI; contraindications for receiving a TMS measurement; more than one seizure per week; missing consent to participate in this study Healthy subjects: Contraindications for receiving an MRI; contraindications for receiving a TMS measurement; more than one seizure per week; missing consent to participate in this study; psychiatric or neurologic diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of resected, functionally-relevant rnTMS stimulation points (points where errors could be elicited during rnTMS stimulation); motor outcome (BMRC score) for upper and lower extremities immediately after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of SMA syndrome; finger tapping score; number of names words in verbal fluency task; cookie theft picture task; quality of life (EORTC-BN20); Number of stimulation points in the healthy SMA, where errors in task completion of the ipsilateral extremity could be elicited (compared to preoperative mapping and healthy subjects) | — |
Countries
Germany
Contacts
Public ContactMelina Engelhardt
Klinik für Neurochirurgie, Charité Universitätsmedizin Berlin
Outcome results
None listed