Detecting perfusion parameters of gingival inflammation by using Laser-Doppler-flowmetry and tissue spectrophotometry- a prospective controlled clinical study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00024048

Enrollment

100

Registered

2021-10-15

Start date

2021-02-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K05.1

Interventions

Group 1: Patients with gingivitis: - Examination of the gingiva at 22 points using Laser-Doppler-flowmetry and tissue spectrophotometry - Clinical examination for inflammation parameters such as incre

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: To be included in our study, patients have to be aged at least 18 years and have to be in good general health (ASA I-II based on the American Society of Anesthesiologists). Further inclusion criteria are: No missing teeth except for the second and third molars, no dental implants in the region of interest and consent to a gingival and periodontal examination. Smokers without signs of gingivitis are excluded as smoking can lead to decreased perfusion of the gum and could therefore mask an underlying inflammation. Patients can only be included if they consent to participate by signing a written informed consent form.

Exclusion criteria

Exclusion criteria: Patients with signs of acute infection or intraoral swelling cannot participate in this study. Further exclusion criteria are: Patients who smoked less than 2 hours before the examination and patients with missing teeth or dental implants.

Design outcomes

Primary

Measure	Time frame
The aim of this prospective controlled clinical study is to determine values for various perfusion parameters such as gingival hemoglobin saturation, blood flow and blood velocity and to compare these with the clinical examination results of patients with and without gingivitis. After the examination of at least 50 patients with and at least 50 patients without gingivitis has been completed, the values of the clinical examinations (probing depths, bleeding on probing, plaque and gingivitis index, biotype) are compared with the results of the perfusion measurements (oxygen saturation, blood flow and velocity, hemoglobin values) and correlations are determined.	—

Measure

Time frame

The aim of this prospective controlled clinical study is to determine values for various perfusion parameters such as gingival hemoglobin saturation, blood flow and blood velocity and to compare these with the clinical examination results of patients with and without gingivitis. After the examination of at least 50 patients with and at least 50 patients without gingivitis has been completed, the values of the clinical examinations (probing depths, bleeding on probing, plaque and gingivitis index, biotype) are compared with the results of the perfusion measurements (oxygen saturation, blood flow and velocity, hemoglobin values) and correlations are determined.

—

Secondary

Measure	Time frame
Evaluation of the perfusion-related and clinical values.	—

Countries

Germany

Contacts

Public ContactMarie Sophie Katz

Klinik für Mund-Kiefer- und Gesichtschirurgie der Uniklinik RWTH Aachen

mkatz@ukaachen.de0241-8088258

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 10, 2026