Role of extracellular calcium in inflammation in obesity or rheumatoid arthrtis

Role of extracellular calcium in inflammation in obesity or rheumatoid arthrtis - exCalOb

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00024017

Enrollment

Registered

2021-03-08

Start date

2016-10-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E66.02 M05.80

Interventions

Group 1: Obese patients, inflammatory type Medical history, physical examination, blood Collection, no intervention Group 2: Obese patients, noninflammatory type Medical history, physical examination,

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - RA: according to ACR/EULAR-criteria 2010, DAS28 > 3.2, stabile tgherapie für 3 months, prednisolon 0,85 (w) or > 1 (m) respectively

Exclusion criteria

Exclusion criteria: Intake of calcium-, Vitamine D-, parathormone or diuretic preparations; endocrinologic disorders, therapy with biologicals, aktive bacterial or viral infection within 2 weeks, leucocytes <3.000/mm³, hypoalbuminemia, GFR < 30 ml/min, i.a. injections within 3 months, malignant disease

Design outcomes

Primary

Measure	Time frame
Calcium-induced IL1ß-release from MDM in cell culture tissue	—

Secondary

Measure	Time frame
- Calcium-induced IL-1ß release in coculture of MDM with adipocytes - Calcium-induced IL-1ß release in MDM with adipose tissue factors present in obesity - Differences in differential blood count, lipid profile, vitamine D	—

Countries

Germany

Contacts

Public ContactStephan Thrum

Universiätsklinikum Leipzig AöRMedizinische Klinik III - Endokrinologie, Nephrologie und RheumatologieBereich Rheumatologie

thrum@uniklinik-leipzig.de03419724355

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026