F06.7 - Mild cognitive disorder F06.8 - Other specified organic mental disorder due to damage or dysfunction of the brain or physical disease F06.9 - Unspecified organic mental disorder due to damage or dysfunction of the brain or physical disease F07.2 - Organic psychosyndrome following traumatic brain injury.Subjects with acquired brain injury, including vascular, inflammatory, traumatic, and neurodegenerative etiologies, are studied. Subjects with a wide range of additional neurological sympt
Conditions
Interventions
Group 1: In a first session, a neuropsychological test battery with conventional paper-and-pencil tests, including the evaluation of spatial memory, is conducted. In a second session, the subjects try
without a controller). In the first block, the memorization and retrieval locations are identical, while in the subsequent block, the subjects' position from where the objects should be placed back is
Sponsors
Tagesklinik für Kognitive Neurologie, Universitätsklinikum Leipzig
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Subjects of any gender with acquired brain injury aged between 18 and 80 years can participate in the planned study. The diagnosis must be confirmed according to the respective disease-specific diagnostic criteria. In addition, the willingness and ability to participate must be fulfilled and a written informed consent must be available. There must be sufficient knowledge of German, linguistic comprehension ability and adequate visual ability.
Exclusion criteria
Exclusion criteria: Subjects with acute psychosis, those suffering from dizziness symptoms or with a history of alcohol or drug abuse cannot participate. Furthermore, subjects who are incapable of giving consent, who lack consent to report any incidental findings, who do not give written consent to participate, or who withdraw consent may not participate. Furthermore, subjects suffering from epilepsy may only participate if the last epileptic seizure occurred more than two years ago and stable medication can be established. Participating women must not be pregnant, planning a pregnancy or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1) The newly developed VR task, the imVMT, is externally validated using neuropsychological test procedures to measure spatial memory. The primary outcome measure is the correlation between performance on the imVMT, measured by mean deviation error (MDE), and standardized neuropsychological test procedures (Rey-Osterrieth Complex Figure Test, immediate recall; Visual and Verbal Memory Test, City Map subtest, immediate recall). | — |
Secondary
| Measure | Time frame |
|---|---|
| (2) Determination of convergent and divergent validity with further neuropsychological test procedures (e.g. Montreal Cognitive Assessment, Trail Making Test, Corsi Block Tapping) and investigation of specificity. (3) Evaluation of the influence of the task variables number of objects (3, 5, 7 objects) and rotation (90°, 180°, 270°) on the MDE. (4) Evaluation of the influence of the task variables number of objects (3, 5, 7 objects) and rotation (90°, 180°, 270°) on the processing time (5) Investigation of feasibility and acceptance of the immersive VR task measured by questionnaires (Simulator Sickness Questionnaire, Motion Sickness Susceptibility Questionnaire) and behavioral observations. (6) System evaluation of the immersive VR task in terms of immersion (Immersive Tendencies Questionnaire, Presence, (Presence Questionnaire. Self-Presence Questionnaire), motivation and usability (VRUSE). | — |
Countries
Germany
Contacts
Public ContactJulia Belger
Tagesklinik für Kognitive Neurologie, Universitätsklinikum Leipzig
Outcome results
None listed