healthy subjects
Conditions
Interventions
Group 1: MINOCIN® Akne Filmtabl (Minocycline), 200mg capsule, oral administration, single-dose.
The experiment will examine whether aversive memories of healthy participants can be influenced by the
Sponsors
Klinik für Psychiatrische Universitätsklinik Zürich
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: - Informed Consent as documented by signature - Age 18 – 40 years
Exclusion criteria
Exclusion criteria: • Allergy to Minocycline or to any other ingredient in the named drugs • Use of any drugs in the 2 weeks prior to the study with the exception of contraceptive drugs and incidental use of NSARs or paracetamol • Women who are pregnant or breast feeding, • Intention to become pregnant during the course of the study, • Lack of safe contraception, defined as: Female participants of childbearing potential, not using and not willing to continue using a medically reliable method of contraception for the entire study duration and for up to 2 weeks after drug intake, such as oral, injectable, or implantable contraceptives, or intrauterine contraceptive devices, or mechanical contraceptive (condom, diaphragm) • Other clinically significant concomitant disease states, e.g., renal failure, cardiovascular disease, etc. • Any history of psychiatric, neurological, dependence or systemic/rheumatic disease • Known or suspected non-compliance, drug or alcohol abuse • Smoking more than 5 cigarettes / day • Inability to follow the procedures of the study, e.g. due to language problems • Participation in another study with investigational drug within the 30 days preceding and during the present study, • Previous enrolment into the current study, • members of the study team and their family members and dependants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fear-potentiated startle, measured via eyeblink EMG of the M. orbicularis oculi and quantified according to Khemka et al. (2017) Detailed analysis plan will be published prior to the start of data analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| SCR (skin conductance response), respiration amplitude, heart period measured with ECG (Electrocardiogram), pupil reaction, questionnaires (STAI). | — |
Countries
Switzerland
Contacts
Public ContactYanfang Xia
Department of Psychiatry, Psychotherapy, Psychosomatics, Psychiatrische Universitätsklinik Zürich, University of Zurich
Outcome results
None listed