Inpatients, hospitalized due to infection with SARS-CoV-2 U07.1
Conditions
Interventions
Group 1: Intervention:
Breathing exercise to stimulate vagal activity to stimulate the cholinergic anti-inflammatory reflex.
Aim: 3x20min daily with 6 breaths per minute and an inhale to exhale ratio
Sponsors
Klinik für Psychosomatische Medizin und Psychotherapie, Uniklinik Ulm
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - SARS-CoV-2-infected patients hospitalized in "normal wards" (Not ICU) with a maximum moderate degree of disease according to RKI/WHO definition (see first exclusion criterion) - Age min. 18 years - Able to give informed consent at the time of study inclusion
Exclusion criteria
Exclusion criteria: - severe covid pneumonia with fever and bilateral lung infiltrates and respiratory rate>30/min or SpO2<90% on room air (adapted from RKI/WHO) - Condition after surgery/trauma/acute event (stroke, myocardial infarction, acute covid-independent infection) in the last 4 weeks - Known pregnancy - Patients with pre-existing pulmonary disease who were on oxygen prior to infection (e.g., due to pulmonary fibrosis, COPD) - limited ability to give consent (e.g. due to dementia) - limited ability to perform breathing maneuvers independently (e.g. high frailty) - limited ability to provide self-care (care level 2 or 3) - lack of language skills - seizures in the medical history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Course of inflammatory parameter IL-6 at admission (day 1) and bi-daily until discharge (average length of stay 10 days, i.e. 5 measurements on average) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.) Course of other inflammatory parameters leukocytes, CRP, TNF-alpha (Bi-daily) 2) subjective dyspnea on admission (day 1) and for two days until discharge (5 measurements), day 30 after discharge 3.) Onset of ventilator requirement and intensive care requirement within 30 days of first hospitalization and death by 30 days after discharge 4.) Length of stay in normal ward 5.) Course of SDNN (recorded on admission and then bi-daily) 6.) Outpatient course (query of Covid-19-associated symptoms such as fatigue 30 days after discharge) | — |
Countries
Germany
Contacts
Public ContactElisabeth Balint
Klinik für Psychosomatische Medizin und Psychotherapie, Uniklinikum Ulm
Outcome results
None listed