COVID-19
Conditions
Interventions
Group 1: SARS-CoV-AK positive, 3 months after infection
Group 2: SARS-CoV-2 negative, healthy controls
Sponsors
Universitätsklinikum FrankfurtInstitut für Neuroradiologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • Nose and / or throat swab with PCR positive result for SARS-CoV-2 • Recovered for at least 3 months at the time of the MRI measurement • Ability to give consent or • Nose and / or throat swab with negative PCR result for SARS-CoV-2 • Negative antibody test • Ability to give consent
Exclusion criteria
Exclusion criteria: - Pregnancy and breast feeding period - Exclusion criteria for an MRT examination: Ferromagnetic metals in the body (containing iron, nickel, cobalt; implants; cardiac defibrillator, pacemaker)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Standard 3D FLAIR measurement for the detection of visible brain lesions 2. Quantitative MRI with T1 mapping, B1 mapping, DTI, and T2 mapping Evaluation: • Visually recognizable damage in the FLAIR (e.g. post-ischemic, post-infectious) • T1 relaxation values ??and T2 relaxation values ??with histograms of the gray and white brain matter and ROI-based measurement of the brain stem, the entorhinal cortex (first connection of the olfactory nerve) and the limbic system • DTI with measurement of FA and mean diffusivity in the white matter of the brain and ROI-based in the brain stem, in the entorhinal cortex and in the limbic system | — |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of CSF and serum parameters of recovered COVID-19 patients and a control collective of subjects that had not contracted COVID-19. Detection of focal neurological or cognitive deficits after a previous SARS-CoV-2 infection. Recording of central respiratory disorder in patients after COVID-19. | — |
Countries
Germany
Contacts
Public ContactElke Hattingen
Universitätsklinikum FrankfurtInstitut für Neuroradiologie
Outcome results
None listed