K90.9 E63.9
Conditions
Interventions
Group 1: Dietary supplement capsules:
1 capsule beta-carotene (30 mg) and 3 capsules lycopene (3x10 mg = 30 mg)
on an empty stomach, orally, with water and 2 slices of toast, one-time intervention
Gro
Sponsors
Initiator: Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: healthy men and women aged 20 to 35 years (= young group) and healthy men and women aged 60 to 75 years (=old goup). BMI between 19 and 29 kg/m².
Exclusion criteria
Exclusion criteria: - regular intake of dietary supplements (multivitamins, carotenoids, trace elements) if subjects are not willing to abstain 3 days before intervention - Active smokers (= 4 cigarettes/day) - History of chronic diseases that affect gastrointestinal function - pregnant women, lactating women - acute, active upper or lower respiratory tract infection - Drastic, unwanted weight loss (>5% last 6 months) - (severe) food intolerances/allergies to tomatoes, carrots, herbs, gluten, nuts - Diabetes Mellitus Type 1 and 2 - Obesity (BMI =30 kg/m²). - Underweight (BMI < 19 kg/m²) - Dementia - Self-reported severe/active liver, kidney, rheumatic diseases, and malignant tumor diseases - hyperlipidemia - Medications that affect fat absorption/metabolism/fat transport - cardiac pacemakers - Consumption of foods rich in lycopene and ß-carotene as well as zinc and selenium (tomatoes, carrots, tomato sauce, ketchup, vegetable juices, sweet potatoes, pumpkin, persimmons, apricots, papaya, mango, nectarines, peaches, pears, sea buckthorn, kale, spinach, broccoli, arugula, peas, cabbage, corn, Brazil nuts, wheat germ) each 3 days before the respective intervention day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bioavailability of carotenoids in young vs. old time points: baseline (0h; before intervention), 90 min, 180 min, 270 min, 360 min (=end) Primary outcome: Area-under-the-curve (AUC) | — |
Secondary
| Measure | Time frame |
|---|---|
| Bioavailability of carotenoids in bread spread and smoothie vs. supplement capsules | — |
Countries
Germany
Contacts
Public ContactVertrauensstelle
Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
Outcome results
None listed